解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Overexpression of the normally imprinted fetal insulin-like growth factor II (IGF2) has been implicated in the pathogenesis of the cancer-predisposing Beckwith-Wiedemann syndrome (BWS). We have detected constitutional relaxation of imprinting of IGF2 in four children with somatic overgrowth who do not show diagnostic ...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/nm0396-311
更新日期:1996-03-01 00:00:00
abstract::Sexual transmission is the most frequent (86%) route of adult HIV-1 transmission worldwide. In the absence of a prophylactic anti-HIV vaccine, other methods of preventing infection should be implemented. Virucidal spermicides have been considered for this purpose, but their application is contraindicated by adverse ef...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/nm0296-230
更新日期:1996-02-01 00:00:00
abstract::Synthetic vascular prostheses are foreign bodies, so that blood coagulation can occur on their luminal surfaces, causing graft occlusion very frequently in prostheses of small diameter. A vascular prosthesis needs angiogenesis for endothelialization of the luminal surface, as endothelial cells have natural and permane...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/nm0196-90
更新日期:1996-01-01 00:00:00
abstract::Although it is presumed that the integration of HIV-1 into the genome of infected CD4+ T lymphocytes allows viral persistence, there has been little direct evidence that CD4+ T cells with integrated provirus function as a latent reservoir for HIV-1 in infected individuals. Using resting CD4+ T-cell populations of extr...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/nm1295-1284
更新日期:1995-12-01 00:00:00
abstract::Internalization of targeted therapeutics is often needed for efficacy, but also alters drug penetration of a tissue. A new model explores the trade-offs of intracellular drug trafficking. ...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/nm1195-1135
更新日期:1995-11-01 00:00:00
abstract::HIV infection can cause extensive neuronal loss and clinically a severe dementia. The cause of the neurotoxicity remains unclear as neurons are not infected, but disturbance of glutamate-linked calcium entry has been implicated. In this study, we have shown a decrease in HIV-infected brain of the expression of mRNA an...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/nm1195-1174
更新日期:1995-11-01 00:00:00
abstract::The rate of expansion of primary prostatic carcinoma is comparatively slow, with tumours frequently taking years or decades to reach clinically relevant size. We now report the presence of an endogenous inhibitor, derived from aqueous extracts of human prostate tissue, which blocks prostatic carcinoma cell proliferati...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/nm1095-1040
更新日期:1995-10-01 00:00:00
abstract::Transforming growth factor beta 1 (TGF-beta 1) is a platelet-derived cytokine involved in both normal wound healing and scarring. We show that human platelets contain two pools of latent TGF-beta 1, which constitute more than 95% of the total TGF-beta assayed in whole platelets. During clotting, one pool, the large la...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/nm0995-932
更新日期:1995-09-01 00:00:00
abstract::CD23 is a low-affinity receptor for immunoglobulin E (IgE) expressed by a variety of haematopoietic cells. Proteolytic cleavage of the transmembrane receptor generates soluble forms, which can be detected in biological fluids. CD23 regulates many functional aspects of immune cells, both in its cell-associated and solu...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/nm0895-781
更新日期:1995-08-01 00:00:00
abstract::We and others have postulated that a constant number of T lymphocytes is normally maintained without regard to CD4+ or CD8+ phenotype ('blind' T-cell homeostasis). Here we confirm essentially constant T-cell levels (despite marked decline in CD4+ T cells and increase in CD8+ T cells) in homosexual men with incident hu...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/nm0795-674
更新日期:1995-07-01 00:00:00
abstract::Proliferation of smooth muscle cells of the arterial wall in response to local injury is an important aetiologic factor of vascular proliferative disorders such as atherosclerosis and restenosis after angioplasty. Ras proteins are key transducers of mitogenic signals from membrane to nucleus in many cell types. We inv...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/nm0695-541
更新日期:1995-06-01 00:00:00
abstract::Previous work from our laboratory demonstrated that selenium deficiency in the mouse allows a normally benign (amyocarditic) cloned and sequenced Coxackievirus to cause significant heart damage. Furthermore, Coxsackievirus recovered from the hearts of selenium-deficient mice inoculated into selenium-adequate mice stil...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/nm0595-433
更新日期:1995-05-01 00:00:00
abstract::Conceptual and practical advances in molecular medicine are changing our understanding of cancer pathogenesis. In time this should provide the opportunity to alter the natural history of many cancers. ...
journal_title:Nature medicine
pub_type: 杂志文章,评审
doi:10.1038/nm0495-309
更新日期:1995-04-01 00:00:00
abstract::Severe malaria is a major cause of childhood mortality in sub-Saharan Africa but the factors predisposing children to severe forms of malaria have not been fully elucidated. In a case-control study of over 1,200 Gambian children hepatitis B virus carriage was significantly increased amongst cases of severe malaria com...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/nm0495-374
更新日期:1995-04-01 00:00:00
abstract::The glycosylation of the circulating immunoglobulin-gamma (IgG) antibody molecules changes in rheumatoid arthritis. The extent of the changes correlates with the disease severity and reverses in remission. We demonstrate here that the alteration in glycosylation associated with rheumatoid arthritis can create a new mo...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/nm0395-237
更新日期:1995-03-01 00:00:00
abstract::We have studied the effects of amyloid beta-peptide analogues on the activity of tissue-type plasminogen activator (t-PA) in vitro. We have found that these peptides have a marked stimulatory effect upon plasminogen activation by t-PA, comparable to that of known stimulators of t-PA. This stimulatory activity appears ...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/nm0295-138
更新日期:1995-02-01 00:00:00
abstract::The search for immunosuppressant drugs to increase the success of organ transplantation led to the discovery of the immunophilins, proteins that interface with a range of signal transduction systems inside cells, especially in the nervous and immune systems. Here we review how these interesting molecules work and cons...
journal_title:Nature medicine
pub_type: 杂志文章,评审
doi:10.1038/nm0195-32
更新日期:1995-01-01 00:00:00
abstract::ATP-induced tumour growth inhibition is accompanied by a selective decrease in the content of the tripeptide glutathione (GSH) within the cancer cells in vivo. Depletion of cellular GSH sensitizes tumours to chemotherapy and radiation, but the usefulness of this depletion depends on whether the levels of GSH can be re...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/nm0195-84
更新日期:1995-01-01 00:00:00